LABORATORY OF NUTRITION AND NEURODEVELOPMENT
Principal Investigator
- Dra. Ana Sofía Vallés
Research lines
Maternal Nutrition and Development
Maternal nutrition is a key environmental determinant during gestation that directly impacts the organization of the developing brain. Based on the concept of fetal programming, we investigate how early metabolic exposures condition susceptibility to diseases in later stages of life (the two-hit hypothesis).
Scientific Approach and Research Focus
We focus on how maternal metabolic syndrome (induced by high-fructose diets) generates a chronic, low-grade inflammatory state that alters the intrauterine environment. Through epigenetic mechanisms, these inflammatory mediators interfere with key neurodevelopmental processes, potentially affecting cognitive, emotional, and behavioral functions in the offspring.
Research Lines
Our approach is multidisciplinary, integrating neuroscience, metabolism, and data analysis across two main areas:
- Basic Researhc: Study of the molecular and cellular mechanisms impacting brain development and behavior in experimental models.
- Clinical Research: Data analysis and statistics in collaboration with clinical laboratories to identify associations and potential biomarkers in human populations.
Outreach and Public Engagement
We promote awareness regarding brain care and healthy habits within the community through outreach activities, including:
- Organization of Brain Awareness Week (workshops, talks, and community/school activities).
- Production of science communication materials, including the development of children’s and young adult literature.
Contact and Social Media:
- Semana del cerebro Bahía Blanca
- Instagram: @semanadelcerebrobb
Researchers/ Fellows
- Dr. Facundo Prado Spalm
- Lic. Daina Cremata
Collaborators
- Dra. Yessica Luquez (UNS)
- Dr. Francisco Barrantes (BIOMED – UCA-CONICET)
- Dr. Agamennoni (IIIE – UNS-CONICET)
- Dra. Schumacher (IIIE – UNS-CONICET)
- Dra. Silenzi (IESS – UNS-CONICET)
- Dr. Delrieux (ICIC – UNS-CONICET)
Former members
- Dra. Marié Cuervo-Sánchez
- Dra. Natalia Furland
Selected Publications
- Vallés AS, Prado Spalm FH, Cuervo Sánchez ML. From maternal metabolism to offspring brain: how high-fructose diets shape neurodevelopment. Trends Neurosci. 2026 Apr 7:S0166-2236(26)00052-4. 10.1016/j.tins.2026.03.006.
- Santiago Valtierra FX, Urriola-Muñoz P, Godoy-Sepúlveda R, Moreno RD, Reyes JG, Vallés AS, Oresti GM. Nonylphenol releases arachidonic acid in rat Sertoli cells via activation of PKA and PLA2. Reproduction. 2024 Jun 13;168(1):e230292. 10.1530/REP-23-0292.
- Cuervo Sánchez ML, Prado Spalm FH, Furland NE, Vallés AS. Pregestational fructose-induced metabolic syndrome in Wistar rats causes sexually dimorphic behavioral changes in their offspring. Dev Neurobiol. 2024 Jul;84(3):142-157. 10.1002/dneu.22940.
- Vallés AS, Barrantes FJ. Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases. Cells. 2023 Aug 11;12(16):2051. 10.3390/cells12162051.
- Prado Spalm FH, Cuervo Sánchez ML, Furland NE, Vallés AS. Lipid peroxidation and neuroinflammation: A possible link between maternal fructose intake and delay of acquisition of neonatal reflexes in Wistar female rats. Dev Neurobiol. 2023 Jul-Sep;83(5-6):167-183. 10.1002/dneu.22921.
Awards
- Premio Early Career Award – International Brain Research Organization (IBRO) – 2024
Contact:
DRA. ANA SOFÍA VALLÉS
svalles@criba.edu.ar
+ 54 291 4037195
