LABORATORY OF ION CHANNELS

Research lines

KCNQ channels are ion channels that mediate the flow of potassium across cell membranes. They play an essential role in regulating electrical potentials in cardiac and neuronal cells. Genetic alterations in these channels are associated with several disorders, including cardiac arrhythmias, epilepsy, and progressive hearing loss.

In our laboratory, we combine structural and functional approaches to understand the underlying mechanisms and develop therapeutic strategies in several areas:

• Ion channel and receptor function in the auditory and nervous systems. We investigate the role of potassium channels in auditory system function and hearing loss using genetically modified mice.
• Biomarkers of hearing loss. We aim to identify specific blood metabolites that can serve as biological markers of hearing impairment. Our goal is to enable early diagnosis of hearing loss, thereby facilitating more effective interventions.
• Development of pharmacological therapies for hearing loss. To maximize treatment efficacy, we implement localized drug-delivery strategies. We use magnetic nanoparticles and hydrogels to deliver otoprotective drugs directly to the site of action, thereby increasing their bioavailability.
• Scientific outreach on hearing health. We organize public talks and participate in science outreach events to raise awareness about hearing health and the importance of hearing protection. Our goal is to translate laboratory findings into practical tools for prevention and health education.